Figure 2 from Presentation of the self antigen myelin basic protein by
Experimental Autoimmune Encephalomyelitis Animal Models Induced by
Cytomembrane Infused Polymer Accelerating Delivery of Myelin Antigen
Figure 1 from The Kinetics of Myelin Antigen Uptake by Myeloid Cells in
(PDF) Nanoparticle-mediated codelivery of myelin antigen and a
VIDEO
AL amyloidosis special session highlights: therapeutic advances and ongoing trials in the field
Autoimmune Encephalitis Series: A Rationale Approach to Diagnostics and Interpretation
Expert Insights on the Rationale for Targeting Epithelial Alarmins in Severe Asthma
Myelin Sheath Attack by T-Cell & Eosinophil
Autoimmune Epilepsy
Autoimmune Encephalitis- Radiological imaging
COMMENTS
Experimental Autoimmune Encephalomyelitis in Mice
Keywords: Experimental autoimmune encephalomyelitis, Multiple sclerosis, Autoimmune disease, Mouse model, CD4 + T cells. 1 Introduction. Multiple sclerosis (MS) is a chronic and debilitating autoimmune disease of the central nervous system (CNS), characterized by lesion formation in the white matter of the brain, spinal cord, and optic nerve (1 ...
Immune Checkpoint Ligand-Bioengineered Schwann Cells as Antigen
Immune Checkpoint Ligand-Bioengineered Schwann Cells as Antigen-Specific Therapy for Experimental Autoimmune Encephalomyelitis. ... The myelin antigen-rich PD-L1 FcIg/CD86 FcIg NP-functionalized MSCs can simultaneously present the myelin antigen to the myelin-specific CD4 + T cells and inhibit PD-1/PD-L1 and CTLA-4/CD86 immune checkpoint pathways.
Critical role of antigen-specific antibody in experimental autoimmune
The role of B cells and antibody in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) remains controversial. We previously demonstrated that B cells are required for EAE to be induced by the 120-amino acid extracellular domain of myelin oligodendrocyte glycoprotein (MOG). In the pr …
Experimental Autoimmune Encephalomyelitis Animal Models Induced by
The experimental allergic encephalomyelitis (EAE) mouse model has been widely used in studying the mechanisms of autoimmune-mediated myelin degradation and testing new therapies for MS 3. Two commonly used animal models of myelin oligodendrocyte glycoprotein (MOG) antigen-induced EAE include MOG 35-55 peptide- and MOG 1-125 (or MOG 1-128 ...
Experimental Autoimmune Encephalomyelitis
Experimental Autoimmune Encephalomyelitis (EAE) is defined as the most widely accepted animal model of multiple sclerosis (MS), used to study the immunogenetic elements and histopathological features of the disease, rather than for testing new treatments. ... Both models can be induced by immunization with myelin antigen (active disease) or by ...
T cells in multiple sclerosis and experimental autoimmune
Studies in experimental autoimmune encephalomyelitis (EAE), an animal model for MS, have provided convincing evidence that T cells specific for self-antigens mediate pathology in these diseases. Until recently, T helper type 1 (Th1) cells were thought to be the main effector T cells responsible for the autoimmune inflammation.
The origin and application of experimental autoimmune encephalomyelitis
Experimental autoimmune encephalomyelitis (EAE) is a model of the neuroimmune system responding to priming with central nervous system (CNS)-restricted antigens. It is an excellent model of post ...
Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic
Moreover, NPs carrying ITE and a peptide corresponding to residues 35-55 of the myelin oligodendrocyte glycoprotein (MOG 35-55) expanded the FoxP3 + Treg compartment and suppressed the development of experimental autoimmune encephalomyelitis (EAE), an experimental model of MS. Thus, NPs are potential new tools for the codelivery of T-cell ...
Experimental Autoimmune Encephalomyelitis
Experimental autoimmune encephalomyelitis (EAE) is a prototypic experimental autoimmune disease that models human multiple sclerosis and that develops in susceptible rodent strains after immunization with myelin basic protein, proteolipid antigen or myelin oligodendrocyte protein (MOG).
Cognate microglia-T cell interactions shape the functional ...
A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2 b mice: fine specificity and T cell receptor Vβ expression of ...
IMAGES
VIDEO
COMMENTS
Keywords: Experimental autoimmune encephalomyelitis, Multiple sclerosis, Autoimmune disease, Mouse model, CD4 + T cells. 1 Introduction. Multiple sclerosis (MS) is a chronic and debilitating autoimmune disease of the central nervous system (CNS), characterized by lesion formation in the white matter of the brain, spinal cord, and optic nerve (1 ...
Immune Checkpoint Ligand-Bioengineered Schwann Cells as Antigen-Specific Therapy for Experimental Autoimmune Encephalomyelitis. ... The myelin antigen-rich PD-L1 FcIg/CD86 FcIg NP-functionalized MSCs can simultaneously present the myelin antigen to the myelin-specific CD4 + T cells and inhibit PD-1/PD-L1 and CTLA-4/CD86 immune checkpoint pathways.
The role of B cells and antibody in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) remains controversial. We previously demonstrated that B cells are required for EAE to be induced by the 120-amino acid extracellular domain of myelin oligodendrocyte glycoprotein (MOG). In the pr …
The experimental allergic encephalomyelitis (EAE) mouse model has been widely used in studying the mechanisms of autoimmune-mediated myelin degradation and testing new therapies for MS 3. Two commonly used animal models of myelin oligodendrocyte glycoprotein (MOG) antigen-induced EAE include MOG 35-55 peptide- and MOG 1-125 (or MOG 1-128 ...
Experimental Autoimmune Encephalomyelitis (EAE) is defined as the most widely accepted animal model of multiple sclerosis (MS), used to study the immunogenetic elements and histopathological features of the disease, rather than for testing new treatments. ... Both models can be induced by immunization with myelin antigen (active disease) or by ...
Studies in experimental autoimmune encephalomyelitis (EAE), an animal model for MS, have provided convincing evidence that T cells specific for self-antigens mediate pathology in these diseases. Until recently, T helper type 1 (Th1) cells were thought to be the main effector T cells responsible for the autoimmune inflammation.
Experimental autoimmune encephalomyelitis (EAE) is a model of the neuroimmune system responding to priming with central nervous system (CNS)-restricted antigens. It is an excellent model of post ...
Moreover, NPs carrying ITE and a peptide corresponding to residues 35-55 of the myelin oligodendrocyte glycoprotein (MOG 35-55) expanded the FoxP3 + Treg compartment and suppressed the development of experimental autoimmune encephalomyelitis (EAE), an experimental model of MS. Thus, NPs are potential new tools for the codelivery of T-cell ...
Experimental autoimmune encephalomyelitis (EAE) is a prototypic experimental autoimmune disease that models human multiple sclerosis and that develops in susceptible rodent strains after immunization with myelin basic protein, proteolipid antigen or myelin oligodendrocyte protein (MOG).
A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2 b mice: fine specificity and T cell receptor Vβ expression of ...